2002-2004: 연세대학교 BK21 연구교수
2010-2013: 과학기술연합대학원대학교(UST, 의약화학 및 약품화학) 겸임교수
2010-2015: 충남대학교 신약전문대학원 학연교수
2016-2017: 미국The Warren Alpert Medical School of Brown University, Cardiovascular Research Center, Visiting Professor
2004-현재: 한국화학연구원 혁신타킷연구센터 책임연구원
주요연구활동
Chemical Genomics/Proteomics
Screening (HTS/HCS) and MOA study
First-in-Class Target Review/Selection/Identification
Drug Discovery (Indications of interest: Cancer, Neurodegenerative Diseases, NASH, Virus)
실험실 및 메일 주소
혁신타킷 치료제 개발 연구실 042-860-7631/7683
메일 주소: hwan@krict.re.kr
논문
1. 치주질환 예방 및 개선제로서 숲개밀 추출물의 효능 대한치과재료학회지 Vol.47,235p~244p 2020.12.31
2. Antibacterial, anti-inflammatory, and anti-osteoclastogenic activities of Colocasia antiquorum var. esculenta: Potential applications in preventing and treating periodontal diseases DENTAL MATERIALS JOURNAL Vol.39,1096p~1102p 2020.12.07
3. Expanding the chemical space: Discovery of new anticancer 3-arylbenzofuran derivatives Journal of heterocyclic chemistry Vol.57,3279p~3293p 2020.10.08
Design, synthesis, and biological evaluation of novel pyrrolo[1,2-a]pyrazine derivatives BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Vol.29,1350p~1356p 2019.04.26
4. Homoharringtonine induces apoptosis in human colorectal carcinoma HCT116 cells via downregulation of Wnt/β-catenin signaling cascade 대한화학회지 Vol.40,196p~199p 2019.01.19
5. Idelalisib inhibits osteoclast differentiation and preosteoclast migration ARCHIVES OF PHARMACAL RESEARCH Vol.42,712p~721p 2019.06.03
6. Anti-osteoclastogenic diacetylenic components of Dendropanax morbifera ARCHIVES OF PHARMACAL RESEARCH Vol.41,506p~512p 2018.06.01
7. Biological evaluation of indolizine-chalcone hybrids as new anticancer agents EUROPEAN J. OF MEDICINAL CHEMISTRY Vol.144,435p~443p 2018.06.01
특허
참꽃마리 추출물을 유효성분으로 포함하는 골질환의 예방 또는 치료용 조성물 20210528 2260037 대한민국
